Chen, Yang-Chao

Fung, Man-Lung

Huang, Yu

Lau, On-Chai

Lo, Chun-Yin

Rudd, John Anthony

Shen, Bing

Tjong, Yung-Wui

Wang, Hui-Chuan

Wong, Ching-On

Yao, Xiaoqiang

Yung, Wing-Ho

Nature Communications

PubMed

AbstractBlood pressure is maintained within a normal physiological range by a sophisticated regulatory mechanism. Baroreceptors serve as a frontline sensor to detect the change in blood pressure. Nerve signals are then sent to the cardiovascular control centre in the brain in order to stimulate baroreflex responses. Here, we identify TRPC5 channels as a mechanical sensor in aortic baroreceptors. In Trpc5 knockout mice, the pressure-induced action potential firings in the afferent nerve and the baroreflex-mediated heart rate reduction are attenuated. Telemetric measurements of blood pressure demonstrate that Trpc5 knockout mice display severe daily blood pressure fluctuation. Our results suggest that TRPC5 channels represent a key pressure transducer in the baroreceptors and play an important role in maintaining blood pressure stability. Because baroreceptor dysfunction contributes to a variety of cardiovascular diseases including hypertension, heart failure and myocardial infarction, our findings may have important future clinical implications.</jats:p

On-Chai Lau

Bing Shen

Ching-On Wong

Yung-Wui Tjong

Chun-Yin Lo

Hui-Chuan Wang

Yu Huang

Wing-Ho Yung

Yang-Chao Chen

Man-Lung Fung

John Anthony Rudd

Xiaoqiang Yao

Crossref

TRPC5 channels participate in pressure-sensing in aortic baroreceptors

Lau, OC

Yung, WH

Huang, Y

Wang, HC

Lo, CY

Tjong, YW

Shen, CO

Rudd, JA

Chen, YC

Yao, X

Fung, ML

HKU Scholars Hub

http://hub.hku.hk/bitstream/10722/244659/1/content.pdf

TRPC5 channels participate in pressure-sensing in aortic baroreceptors

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HKU Scholars Hub