Green, DW

Jung, HS

Kim, EJ

Kim, HY

Lee, JM

Lee, KH

Watson, GS

Watson, JH

Yoon, KS

Scientific Reports

PubMed

The external epithelial surfaces of plants and animals are frequently carpeted with small micro- and nanostructures, which broadens their adaptive capabilities in challenging physical habitats. Hairs and other shaped protuberances manage with excessive water, light contaminants, predators or parasites in innovative ways. We are interested in transferring these intricate architectures onto biomedical devices and daily-life surfaces. Such a project requires a very rapid and accurate small-scale fabrication process not involving lithography. In this study, we describe a simple benchtop biotemplating method using shed gecko lizard skin that generates duplicates that closely replicate the small nanotipped hairs (spinules) that cover the original skin. Synthetic replication of the spinule arrays in popular biomaterials closely matched the natural spinules in length. More significantly, the shape, curvature and nanotips of the synthetic arrays are virtually identical to the natural ones. Despite some small differences, the synthetic gecko skin surface resisted wetting and bacterial contamination at the same level as natural shed skin templates. Such synthetic gecko skin surfaces are excellent platforms to test for bacterial  control in clinical settings. We envision testing the biocidal properties of the well-matched templates for fungal spores and viral resistance in biomedicine as well as co/multi-cultures

Green, David William

Lee, Kenneth Ka-Ho

Watson, Jolanta A

Kim, Hyun-Yi

Yoon, Kyung-Sik

Kim, Eun-Jung

Lee, Jong-Min

Watson, Gregory S

Jung, Han-Sung

USC Research Bank - University of the Sunshine Coast

High Quality Bioreplication of Intricate Nanostructures from a Fragile Gecko Skin Surface with Bactericidal Properties

HKU Scholars Hub

High Quality Bioreplication of Intricate nanostructures from a Fragile Gecko Skin Surface with Bactericidal Properties

http://hub.hku.hk/bitstream/10722/237750/1/content.pdf

High Quality Bioreplication of Intricate nanostructures from a Fragile Gecko Skin Surface with Bactericidal Properties

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USC Research Bank - University of the Sunshine Coast

HKU Scholars Hub