Methods utilize mathematical equations and models and specialized computer techniques. Techniques apply to food production, complex chemicals production, and polluted water purification

Edwards, V. E.

Wilke, C. R.

English

NASA Technical Reports Server

Brief 71-10192 
AEC-NASA TECH BRIEF 
0 
Lawrence Radiation Laboratory 
June-1971 
..1*
NASA Tech Briefs announce new technology derived from the U.S. space program. They are issued to encourage 
commercial application. Tech Briefs are available on a subscription basis from the National Technical Information 
Service, Springfield, Virginia 22151. Requests for individual copies or questions relating to the Tech Brief program may 
be directed to the Technology Utilization Office, NASA, Code KT, Washington, D.C. 20546. 
Analytical Methods for Bacterial Kinetics Studies 
Analytical methods for studying the kinetics of 
bacterial growth and metabolism, utilizing mathe-
matical equations and models and specialized com-
puter techniques, have been reviewed. The study of 
bacterial kinetic activity is applicable to fields 
as far ranging as food production, complex chemicals 
production, and polluted water purification. Through 
the methods developed, a better understanding of 
such activity can be achieved, greater control over 
the processes involved can be made possible, 
and optimal process conditions over a broad range 
tions. 
The data presented in the report were obtained 
with a salt-tolerant strain of sulfate-reducing bacteria 
grown in both batch and continuous cultures. The 
results of the computer analysis of this data are 
discussed in relation to some of the proposed 
mathematical models. The report also includes a 
description of a novel continuous-culture apparatus 
used in these experiments.
The apparatus used for measuring bacterial cell 
size-concentration distributions employs a measure-
ment technique which differentiates between normal 
cells and heat-killed cells, a result that should be of 
considerable value in the study of bacterial steriliza-
tion kinetics. The apparatus was calibrated and used 
in obtaining information on the cell size under a 
variety of experimental conditions. A computer 
program was used to analyze the computer-coupled 
output. 
Note: 
The following documentation is available from: 
Technical Information Division 
Lawrence Radiation Laboratory 
University of California 
Berkeley, California 94720 
Reference: 
UCRL-16398,	 Analytical	 Methods	 in 
Bacterial Kinetics 
Patent status: 
No patent action is contemplated by AEC or NASA. 
Source: V. E. Edwards and C. R. Wilke of 
Lawrence Radiation Laboratory 
(LRL-1001 1) 
S of variables can be predicted. The computer technique described is applicable to 
the analysis of batch culture kinetic data and is 
used for fitting equations to the data. The equations 
can then be used for data interpolation, extrapola-
tion, integration, differentiation, and other manipula-
Category 05 
This document was prepared under the sponsorship of the National 
Aeronautics and Space Administration. Neither the United States 
Government nor any person acting on behalf of the United States
Government assumes any liability resulting from the use of the 
information contained in this document, or warrants that such use 
will be free from privately ownedrights.
https://ntrs.nasa.gov/search.jsp?R=19710000191 2020-03-17T02:24:28+00:00Z


Analytical methods for bacterial kinetics studies

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