Gambaran Histopatologik Lambung Tikus Wistar Yang Diberikan Buah Pepaya Sebelum Induksi Aspirin

Abstract

: Aspirin contains acetyl salicylic acid which can cause qualitative change on the gastric mucosa. The active ingredients of papaya can increase immunity and protect the stomach from the use of aspirin and steroid. Objective: To reveal the histophatological features of the stomach of Wistar rats administered with papaya juice before aspirin induction. Method: This experimental research employed 20 wistar rats which were divided into the negative control group (A) and treatment groups. All rats were fed with regular or standard pellets for 10 days. Treatment groups were classified into four groups; rats were given papaya juice of 0.8 cc/day (group B), rats were administered aspirin of 30 mg/day (group C), rats were given papaya juice 0.8 cc/day before induced with aspirin (group D), and rats were given papaya juice 2.4 cc/day before induced with aspirin of 30 mg/day (group E). On the eleventh day, the rats were terminated to isolate the stomach followed by macroscopic and microscopic examinations. Results: It was found that the microscopic features were normal in negative control group and group B. In group C, histological examination showed acute gastritis, i.e.,inflammatory cells, edema mucosa and capillary dilatation. Rats in group D and E showed lower degree of acute gastritis compared with group C. Conclusions: Administration of papaya juice for 10 days before aspirin is given may reduce the signs of acute gastritis as demonstrated by histopathological features of the stomach of wistar rats. Administration of papaya juice of 2.4 cc/day result in lower degree of gastritis compared with recommended dose of papaya juice (0.8 cc/day)