Virus it the microscopic of measured parasite, to infection the organism cell, and only reproducing in know that there is antiviral activity from the ethanol extract of Sirih Merah leaf (Piper crocatum Ruitz & Pav) into Newcastle Disease virus with thin layer chromatography profile. The extract made by the maceration method with using the ethanol 96%. This research did conducting in ovo, there is chicken's egg embryo with the age 9 – 10 days. The inspection of hindrance virus is used for hemaglutination test (HA test). This research analyze with the anava test. The resulting of research indicates that the ethanol extract of Sirih Merah leaf can delay the growth Newcastle Disease virus. The concentration third of this show that more increase of concentration, the higgest 94,79% of purpose to 50%. For knowing which one of more potent between concentration of third to Newcastle Disease virus with used BNT test, those result to show the different of meaning manner statistic (P < 0,05), it means of that the activity of antiviral ethanol extract Sirih merah leaf to Newcastle Disease virus has the different meaning between 1 µg/ml with 10 µg/ml and 1 µg/ml with 100 µg/ml concentration. Activity of antiviral ethanol extract sirih merah leaf is 10 µg/ml manner statisticEthanol extract Sirih Merah leaf have content of chemical compound like flavonoid, saponin, tannin.
Keyword : antiviral, ethanol extract, sirih merah leaf, Newcastle Disease, thin layer chromatography
