Gambaran Makroskopik Dan Mikroskopik Pankreas Pada Hewan Coba Postmortem

Abstract

: Medicolegal examination is beneficial in police investigation inter alia to determine the time of death and causes as well as mechanisms of death. Postmortem macroscopic and microscopic changes could be alternatives to estimate the time of death. This study was aimed to obtain the microscopic and macroscopic postmortem changes in pancreas based on the variation of time up to 48 hours. This was a descriptive observational study using two domestic pigs as animal model. Pancreas samples were obtained at time intervals as follows: 0 hour, 1 hour, 2 hours, 3 hours, 4 hours, 5 hours, 6 hours, 8 hours, 10 hours, 12 hours, 14 hours, 16 hours, 18 hours, 20 hours, 22 hours, 24 hours, 26 hours, 28 hours, 30 hours, 33 hours, 36 hours, 39 hours, 42 hours, and 48 hours postmortem. The macroscopic examination showed changes in its consistency at 8 hours postmortem, followed by changes in color, consistency, and length during 39 hours postmortem. Microscopic changes of pancreas occurred at 2 hours postmortem as congestion of the acini. At 5 hours postmortem, the acinar cells were difficult to be identified; most of their nuclei were distributed out of the cells. At 8 hours postmortem the structures of acini could not be identified and the cells had undergone karyolysis. At 10 hours postmortem the structures of all acini could not be identified. Conclusion: Postmortem macroscopic changes of pancreas began at 8 hours postmortem meanwhile microscopic changes began at 2 hours postmortem as acinar congestion. At 8 hours postmortem most acini's structures could not be identified and their cells' nuclei underwent karyolysis