New plastic compositions, involving the systhesis of a polymeric system containing heparin insolubilized with crosslinking agents, show appreciable promise in human body implant technology

Rembaum, A.

English

NASA Technical Reports Server

August 1969	 Brief 69-10299 
NASA TECH BRIEF 
-- t:ii- ----------. 	 .------	 ::i	 -	 ; 
NASA Tech Briefs are issued to summarize specific innovations derived from the U.S. space program, 
to encourage their commercial application. Copies are available to the public at 15 cents each 
from the Clearinghouse for Federal Scientific and Technical Information, Springfield, Virginia 22151. 
Heparin Insolubilized with Crosslinking Agent 
Certain new plastic compositions have been formed 
that show appreciable promise in the field of human 
body implant technology. These involve the syn-
thesis of a polymeric system containing heparin in-
solubilized with crosslinking agents. Copolymeri-
zation is effected by means of cobalt, gamma, photo-
chemical, and other similar irradiation. 	 - 
It has been disclosed that a new family of water 
soluble dicationic crosslinking agents having utility 
in the preparation of polymers of various types exists. 
Supplementary to this disclosure, the dicationic cross-
linking agents are found to form polymers with acrylic 
acid, acrylamide, methacrylamide, hydroxy ethylmeth-
acrylate, barium acrylate, dimethylamino ethyl meth-
acrylate, etc. 
In another aspect, it is determined that water 
soluble sulfonate pdlymers such as sodium vinyl sul-
foriate are insolubilized by crosslinking with dicationic 
crosslinking agents by reaction either in solution or 
in bulk. In an extension of work on sodium vinyl 
sulfonate, commercially available heparin (a polymer 
with sulfated groups) is also insolubilized by the 
reaction with the above dicationic crosslinking agents 
in water, using various concentrations of each com-
ponent, and polymerizing by means of standard redox 
systems. The water-insoluble product serves as a 
filler in known polymers, providing final polymeric 
composites with anti-coagulant properties. In water 
solution, heparin is a polysaccharide with sulfate and 
carboxylic groups forming an acidic polyanion. It 
is believed that R-OS0 3Na and R-NIH-S0 3Na groups 
of heparin are the reactive centers linking with func-
tional groups of the cationic crosslinking agents. In 
addition, it is found that mixtures of hydroxyethyl-
methacrylate and heparin are rendered water-insolu-
ble by crosslinking with the dicationic agents. Cellu-
losic materials, including paper and wood can be 
impregnated with solutions and further polymerized 
to provide materials having polyelectrolyte charac-
teristics. The crosslinking may be effected on the 
surfaces of films, filaments, or particles of any such 
polymeric material. Bonding and grafting on polymer 
surfaces may alternatively be achieved by cobalt 
gamma irradiation, photochemical irradiation, and 
the like, to previously achieved heparinized surfaces 
rather than by crosslinking with persulfate—bisulfite 
redox systems. Combinations of such methods may 
also be used. 
Notes: 
1. In preliminary screening tests, a number of the 
heparinized polymeric materials prepared have 
shown blood anti-coagulant properties. This sug-
gests utility as heparinized membranes and as 
treated plastics for body implant purposes. 
2. Documentation is available from: 
Clearinghouse for Federal Scientific 
and Technical Information 
Springfield, Virginia 22151 
Price $3.00 
Reference: TSP69-1 0299 
Patent status: 
No patent action is contemplated by NASA. 
Source: Dr. Alan Rembaum
NASA Pasadena Office 
(NPO-10834)
Category 03 
This document was prepared under the sponsorship of the National 
Aeronautics and Space Administration. Neither the United States 
Government nor any person acting on behalf of the United States
Government assumes any liability resulting from the use of the 
information contained in this document, or warrants that such use 
will be free from privately owned rights.
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Heparin insolubilized with crosslinking agent

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