: Chronic kidney disease (CKD) is a pathophysiological process with a variety of etiology, causing a progressive decline in kidney function, and generally ends with kidney failure. Although significant progress has been made for the treatment of CKD, it was not satisfying yet, especially at the final stage of the disease. Reducing salt intake is one of the options. Approximately, 60% of non-dialysis CKD patients suffered from hyponatremia with normal chloride levels. This study aimed to obtain the profile of the sodium and chloride levels in non-dialysis CKD patients. This was a descriptive study and was carried out at two hospitals, Prof. Dr. R. D. Kandou Hospital Manado and Advent Hospital Manado. Samples were blood samples of 35 patients suffering from stage 5 non-dialysis CKD determined by using consecutive sampling of non-probability sampling model. The results showed that based on the laboratory result, there were 19 patients diagnosed with stage 5 non-dialysis CKD with hyponatremia (54.3%) and 19 patients with imbalance chloride levels consisted of 8 patients with hypochloremia (22.9%) and 8 patients with hyperchloremia (22.9%). Conclusion: In stage five non-dialysis chronic kidney disease patients, sodium and chloride imbalance commonly occurred as hyponatremia, however, hypo and hyperchloremia had the same occurence