Hubungan Kadar Albumin Plasma Dan Gula Darah Dengan Sepsis Neonatorum

Abstract

. Sepsis is the most leading cause of morbidity and mortality in neonates. In sepsis, the proinflammatory cytokines realeasing leads to disruption of plasma albumin and blood glucose levels. This study aim to analyze the relationship of plasma albumin and blood sugar levels with neonatal sepsis. Prospective observational analytic studies conducted on suspected sepsis neonates at Pediatrics Department Sub Division Neonatology RSUP Prof.Kandou Manado. Diagnosis of sepsis based on clinical symptoms and laboratory tests. Subjects are grouped into two groups of neonatal sepsis and non-neonatal sepsis group (control group). Plasma albumin and blood glucose level examined, then statistically analyzed. The statistical analysis used was Pearson Chi-Square correlation and Fisher Exact. The data were processed using SPSS 21. The results of this study indicate that hypoalbuminemia was found in 12 (75%) of 16 neonatal sepsis subject, whereas in non-neonatal sepsis only found 5 (22,7%) of 22 non-sepsis subjects. Statistically there is a highly significant difference (p=0,001). For the impaired blood glucose (both hypoglycemia or hyperglycemia) there is no significant difference between the two groups (p=0,466).Conclusion: There is a highly significant relationship between hypoalbuminemia with neonatal sepsis. There was no significant correlation between abnormal blood glucose levels with neonatal sepsis