The research will be carried out this has the objective to determine the physical properties of the gel extracts Phaleria with CMC and Aqupec base 505. And can determine the effects of both the base of the primary irritation. This research will be formulated gel Mahkota Dewa fruit extract with CMC and Aqupec base 505. Furthermore, the two formulas are tested physical properties and primary irritation test. Test physical properties include organoleptic test, measurement of pH and viscosity of both the gel formula. In the gel formula III skin and fruit seed extracts gods crown with CMC-Na base gives greater irritant effects (moderate irritant). This is possible because CMC-Na is a surfactant that can reduce the surface tension and the viscosity is too low, it can not maintain (control) release of active substances causing excessive absorption of the active substance by the epidermis. Since the solvents used in the extraction of toxic irritant effects were larger (heavier). organoleptic In conclusion, the formula I and III undergo physical changes during storage. In addition, the difference in the base gel viscosity and pH influence the gel preparation. Gel base Aqupec HV 505 is more appropriate for active substances compared with CMC-Na gel base. Because the gel base Aqupec 505 HV to maintain the physical properties of the test and a little irritation to stimulate irritant effect.
Keyword : primary iritation, Mahkota dewa, CMC Na, Aqupect
