Infection by Treponema pallidum still represents a clinical challenge due to its various forms of presentation. HIV coinfection added diversity and changed the natural history of syphilis as a systemic infection. We present a rare case of subacute hypophysitis and panhypopituitarism due to an early active neurosyphilis in a previously unknown HIV coinfected patient.info:eu-repo/semantics/publishedVersio

Alves, R.

França, M.

Case Reports in Infectious Diseases

Infection by Treponema pallidum still represents a clinical challenge due to its various forms of presentation. HIV coinfection added diversity and changed the natural history of syphilis as a systemic infection. We present a rare case of subacute hypophysitis and panhypopituitarism due to an early active neurosyphilis in a previously unknown HIV coinfected patient

Rute Alves

Margarida França

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Subacute Hypophysitis with Panhypopituitarism as First Presentation of HIV and Syphilis Coinfection

Infection by Treponema pallidum still represents a clinical challenge due to its various forms of presentation. HIV coinfection added diversity and changed the natural history of syphilis as a systemic infection. We present a rare case of subacute hypophysitis and panhypopituitarism due to an early active neurosyphilis in a previously unknown HIV coinfected patient.</jats:p

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Case ReportSubacute Hypophysitis with Panhypopituitarism asFirst Presentation of HIV and Syphilis CoinfectionRute Alves andMargarida FrançaClinical Immunology Unit, Centro Hospitalar do Porto, Porto, PortugalCorrespondence should be addressed to Rute Alves; ruteifalves@gmail.comReceived 31 July 2016; Accepted 6 March 2017; Published 16 April 2017Academic Editor: Larry M. BushCopyright © 2017 Rute Alves and Margarida Franc¸a. This is an open access article distributed under the Creative CommonsAttribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work isproperly cited.Infection byTreponema pallidum still represents a clinical challenge due to its various forms of presentation. HIV coinfection addeddiversity and changed the natural history of syphilis as a systemic infection. We present a rare case of subacute hypophysitis andpanhypopituitarism due to an early active neurosyphilis in a previously unknown HIV coinfected patient.1. IntroductionInfection by Treponema pallidum is a common world-wide sexually transmitted disease that is a systemic con-dition, clinically polymorphic and typically evolving bystages. It is remarkable for its pathological interaction withhuman immunodeficiency virus (HIV): it facilitates HIVtransmission and increases plasma and cerebrospinal fluid(CSF) HIV-RNA levels [1]. For its part, HIV itself canalter the clinical course of syphilis [2], adding semiologicdiversity with more frequent early syphilitic neurologicaland ophthalmic involvement, increasing the probability ofrelapse, and making the diagnosis of neurosyphilis a clinicalchallenge.Inflammatory condition of the pituitary gland (hypo-physitis) is rare condition and its incidence (one case per9 million people per year) has been estimated mainly fromscarce case series reporting data from surgeries or necropsyspecimens [3]. Secondary granulomatous form is even moreunique (21 histologically confirmed cases) and syphilis isone of the documented etiologies [4]. Panhypopituitarism(hyposecretion of 3 or more of pituitary produced hor-mones) is one of the possible presentations. To the best ofour knowledge, this is the second report in literature ofsymptomatic hypophysitis with panhypopituitarism due toacquired syphilis in an HIV patient.2. Case PresentationIn July 2014, a Portuguese 42-year-old male reported suddenpainless right central loss of vision with no photophobia,discharge, or trauma. He had a history of malaise and mildand intermittent holocranial headaches, with no associatednausea, vomiting, or photophobia, for the last 3 months. Theheadaches became progressively severe in the last 15 days,interfering with sleep and daily activities, associated withprogressively worsening gait imbalance and anorexia. He alsonoticed cold intolerance, erectile dysfunction, and decreasedlibido, without constipation, polydipsia, polyuria, or periph-eral edema. He correlated the symptoms with exhaustingworking hours and he did not seek medical attention. He alsoreferred to a generalized pruriginous skin rash with 1-monthevolution. His past medical history was unremarkable, exceptfor smoking habits and unprotected homosexual intercourse.At presentation in our emergency room he looked under-nourished (BMI = 19Kg/m2) with asymptomatic low bloodpressure (90/62mmHg). He had facial seborrheic eczema,generalized cutaneous erythematous maculae with distinctedges including palms and soles (Figure 1), a small nontenderulcer in the inferior lip, and a smooth nontender mildhepatomegaly. His pupils were equal, round, and reactive tolight and accommodation and extraocular movements wereintact, not suggestive of Argyll-Robertson pupils. He showedHindawiCase Reports in Infectious DiseasesVolume 2017, Article ID 1489210, 3 pageshttps://doi.org/10.1155/2017/14892102 Case Reports in Infectious DiseasesFigure 1: Generalized cutaneous erythematous maculae with distinct edges.Baseline 25-Jul-2014(a)Follow-up #1 26-Mar-2015(b)Figure 2: Macular optic computed tomography of right eye, during active disease (a). Small vitreous inflammatory agglomerates andinflammatory deposits in neurossensorial retina; diffuse macular thickening. After resolution (b).gait ataxia without proprioceptive impairment and bilateralpositive finger-nose-finger test. He had a central scotomain the right eye, with initially preserved peripheral visionthat rapidly deteriorated; fundoscopy was highly suggestiveof panuveitis, with fine keratic granulomatous precipitates,aqueous cells, flare grade 1, and choroidal and subretinalinfiltration in the posterior pole (Figure 2(a)).Cerebral computed tomography ruled out space occu-pying lesions or signs of high intracranial pressure. CSFanalysis showed lymphocytic pleocytosis (48 cells/uL) withhigh level protein (0,89 g/L). Given the patient’s social historywith risk for sexually transmitted infections,HIV and syphiliswith uveitis and meningitis were high on the differential. Hewas hospitalized for investigation. Initial laboratory resultsrevealed leukopenia (3520/𝜇L) with lymphopenia (1340/𝜇L)and a positive HIV serology with CD4 cell count of 264/𝜇L(18,4%; CD4/CD8-ratio 0,34). HIV viral load was 54700copies/mL (log 4,74). He had a serum VDRL positive at64 “dils,” with positive IgM antibody. CSF VDRL wasnegative, and CSF HIV-RNA was 3290 copies/ml. Bacterial,fungal, viral, and mycobacterial organisms in CSF wereexcluded. Thyroid-stimulating hormone (TSH) was sup-pressed (0,26mUI/mL) and free thyroxine (fT4) had a lowvalue (0,43 ng/dl). MRI of the sella turcica showed pitu-itary heterogeneous enlargement with peripheral contrastenhancement, with no pituitary stalk thickening (Figure 3).Extended endocrine study also showed low levels of basalcortisol (1,5 𝜇g/dL), luteinising-hormone (0,6mUI/ml), andtestosterone (0,025 ng/mL). He underwent a 14-day regimenof penicillin G and was started on hormone reposition:high dose prednisolone (due to concomitant panuveitis) andlevothyroxine (75𝜇g qd). He was discharged after 15 days,with complete resolution of headache, improvement of visualacuity, and more coordinated and steady gait. Hormone val-ues normalized within days. He was started on antiretroviraltherapy in October 2014, with tenofovir/emtricitabine andefavirenz, presenting undetectable HIV-RNA since August2015. In July 2016 he presented a CD4 cell count of 510/𝜇l(27,4%), positive TPHA, and negative (2 “dils”) VDRL. Thefivefold decrease in VDRL titers (4 dils) occurred in thefirst fourmonths after penicillin treatment. During follow-uphormone replacement therapies were gradually tapered alongwith neurological and ocular improvement until completeresolution (Figure 2(b)). MRI of the sella turcica 10 monthslater showed an almost normal pituitary size with dis-crete heterogenous enhancement (Figure 4). Nowadays theCase Reports in Infectious Diseases 3Figure 3: MRI of sella turcica at admission (August 2014): heteroge-neous enlargement with peripheral contrast enhancement.Figure 4: MRI of sella turcica at 10-month follow-up (May 2015):normal pituitary size with discrete heterogenous enhancement.patient remains asymptomatic. In conclusion, HIV1 infectionand an early syphilis infection (stage II) with neurologicalinvolvement—panuveitis, meningitis, and hypophysitis withpanhypopituitarism—were diagnosed.The high activity of T.pallidum infection was illustrated by positive specific serumIgM antibody and the early neurosyphilis presentation withhypophysitis was corroborated by CSF abnormalities andMRI findings and sustained clinical, neurological, endocrino-logical, and serological recovery after specific treatment.3. DiscussionSyphilis has been a persistent challenge for centuries andis now regaining attention along with the HIV pandemic[5]. The interaction between syphilis and HIV infection iscomplex and remains incompletely understood, despite thesignificative clinical experience with coinfected patients [6].The course of syphilis within a depressed immune systemclearly differs from that inHIV-negative patients [1, 2, 5], withaccelerated development of early and late neurologic sequelae[7]. The diagnosis of neurosyphilis in coinfected patientsrequires a high index of suspicion, as the CSF abnormalitiesdue to Treponema and HIV often overlap. On the otherhand, CSF VDRL can be negative in the presence of activedisease, and the favorable response to treatment plays asignificant role to confirm the diagnosis. This case illustratesthe multiplicity of attainments of syphilis, an infection thatthough recognized for centuries continues to cause surprise,especially in the HIV era.Conflicts of InterestThe authors declare that they have no conflicts of interestrelevant to this paper.AcknowledgmentsThanks are due to Dr. Vasco Miranda from OphthalmologyDepartment for his contribution to this paper.References[1] E. Firlag-Burkacka, P. Swiecki, I. Cielniak et al., “High frequencyof neurosyphilis in HIV-positive patients diagnosed with earlysyphilis,” HIV Medicine, vol. 17, no. 5, pp. 323–326, 2016.[2] D. R. Johns, M. Tierney, and D. Felsenstein, “Alteration in thenatural history of neurosyphilis by concurrent infection withthe human immunodeficiency virus,”The New England Journalof Medicine, vol. 316, no. 25, pp. 1569–1572, 1987.[3] P. Caturegli and S. Iwama, “From Japan with love: anothertessera in the hypophysitis mosaic,” The Journal of ClinicalEndocrinology &Metabolism, vol. 98, no. 5, pp. 1865–1868, 2013.[4] R. Carpinteri, I. Patelli, F. F. Casanueva, and A. Giustina,“Inflammatory and granulomatous expansive lesions of thepituitary,”Best Practice andResearch: Clinical Endocrinology andMetabolism, vol. 23, no. 5, pp. 639–650, 2009.[5] L.M.Chahine, R.N.Khoriaty,W. J. Tomford, andM. S.Hussain,“The changing face of neurosyphilis,” International Journal ofStroke, vol. 6, no. 2, pp. 136–143, 2011.[6] N.M. Zetola and J. D. Klausner, “Syphilis and HIV infection: anupdate,”Clinical InfectiousDiseases, vol. 44, no. 9, pp. 1222–1228,2007.[7] G. Karp, F. Schlaeffer, A. Jotkowitz, and K. Riesenberg, “Syphilisand HIV co-infection,” European Journal of Internal Medicine,vol. 20, no. 1, pp. 9–13, 2009.Submit your manuscripts athttps://www.hindawi.comStem CellsInternationalHindawi Publishing Corporationhttp://www.hindawi.com Volume 2014Hindawi Publishing Corporationhttp://www.hindawi.com Volume 2014MEDIATORSINFLAMMATIONofHindawi Publishing Corporationhttp://www.hindawi.com Volume 2014Behavioural NeurologyEndocrinologyInternational Journal ofHindawi Publishing Corporationhttp://www.hindawi.com Volume 2014Hindawi Publishing Corporationhttp://www.hindawi.com Volume 2014Disease MarkersHindawi Publishing Corporationhttp://www.hindawi.com Volume 2014BioMed Research InternationalOncologyJournal ofHindawi Publishing Corporationhttp://www.hindawi.com Volume 2014Hindawi Publishing Corporationhttp://www.hindawi.com Volume 2014Oxidative Medicine and Cellular LongevityHindawi Publishing Corporationhttp://www.hindawi.com Volume 2014PPAR ResearchThe Scientific World JournalHindawi Publishing Corporation http://www.hindawi.com Volume 2014Immunology ResearchHindawi Publishing Corporationhttp://www.hindawi.com Volume 2014Journal ofObesityJournal ofHindawi Publishing Corporationhttp://www.hindawi.com Volume 2014Hindawi Publishing Corporationhttp://www.hindawi.com Volume 2014 Computational and  Mathematical Methods in MedicineOphthalmologyJournal ofHindawi Publishing Corporationhttp://www.hindawi.com Volume 2014Diabetes ResearchJournal ofHindawi Publishing Corporationhttp://www.hindawi.com Volume 2014Hindawi Publishing Corporationhttp://www.hindawi.com Volume 2014Research and TreatmentAIDSHindawi Publishing Corporationhttp://www.hindawi.com Volume 2014Gastroenterology Research and PracticeHindawi Publishing Corporationhttp://www.hindawi.com Volume 2014Parkinson’s DiseaseEvidence-Based Complementary and Alternative MedicineVolume 2014Hindawi Publishing Corporationhttp://www.hindawi.com

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Subacute Hypophysitis with Panhypopituitarism as First Presentation of HIV and Syphilis Coinfection

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