Bringing together state-of-the-art high-performance computing, remote sensing and spatial information sciences, we establish a method of real-time tsunami inundation forecasting, damage estimation and mapping to enhance disaster response. Right after a major (near field) earthquake is triggered, we perform a real-time tsunami inundation forecasting with use of high-performance computing platform. Given the maximum flow depth distribution, we perform quantitative estimation of exposed population using census data and the numbers of potential death and damaged structures by applying tsunami fragility curve. After the potential tsunami-affected areas are estimated, the analysis gets focused and moves on to the "detection" phase using remote sensing. Recent advances of remote sensing technologies expand capabilities of detecting spatial extent of tsunami affected area and structural damage. Especially, a semi-automated method to estimate building damage in tsunami-affected areas is developed using optical sensor data and a set of pre-and post-event high-resolution SAR (Synthetic Aperture Radar) data. The method is verified through the case studies in the 2011 Tohoku and other potential tsunami scenarios, and the prototype system development is now underway in Kochi prefecture, one of at-risk coastal city against Nankai trough earthquake. In the trial operation, we verify the capability of the method as a new tsunami early warning and response system for stakeholders and responders
