We observe an obvious anomalous line-shape of the e+e−→hadrons total cross sections in the energy region between 3.700 and 3.872 GeV from the data samples taken with the BES-II detector at the BEPC Collider. Re-analysis of the data shows that it is inconsistent with the explanation for only one simple ψ(3770) resonance with a statistical significance of 7σ. The anomalous line-shape may be explained by two possible enhancements of the inclusive hadron production near the center-of-mass energies of 3.764 GeV and 3.779 GeV, indicating that either there is likely a new structure in addition to the ψ(3770) resonance around 3.773 GeV, or there are some physics effects reflecting the DDˉ production dynamics