Ampofo, Stephen

Boyd, Peter

Edwards, Karen-Leigh

Fetherston, Susan M.

Malcolm, R. Karl

McBride, Marcella C.

McCoy, Clare F.

Susan M. Fetherston

Peter Boyd

Clare F. McCoy

Marcella C. McBride

Karen-Leigh Edwards

Stephen Ampofo

R. Karl Malcolm

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European Journal of Pharmaceutical Sciences

A silicone elastomer vaginal ring for HIV prevention containing two microbicides with different mechanisms of action

Vaginal rings are currently being developed for the long-term (at least 30 days) continuous delivery of microbicides against human immunodeficiency virus (HIV). Research to date has mostly focused on devices containing a single antiretroviral compound, exemplified by the 25 mg dapivirine ring currently being evaluated in a Phase III clinical study. However, there is a strong clinical rationale for combining antiretrovirals with different mechanisms of action in a bid to increase breadth of protection and limit the emergence of resistant strains. Here we report the development of a combination antiretroviral silicone elastomer matrix-type vaginal ring for simultaneous controlled release of dapivirine, a non-nucleoside reverse transcriptase inhibitor, and maraviroc, a CCR5-targeted HIV-1 entry inhibitor. Vaginal rings loaded with 25 mg dapivirine and various quantities of maraviroc (50– 400 mg) were manufactured and in vitro release assessed. The 25 mg dapivirine and 100 mg maraviroc formulation was selected for further study. A 24-month pharmaceutical stability evaluation was conducted, indicating good product stability in terms of in vitro release, content assay, mechanical properties and related substances. This combination ring product has now progressed to Phase I clinical testing

Queen's University Belfast Research Portal

A silicone elastomer vaginal ring for HIV prevention containing two microbicides with different mechanisms of action

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Queen's University Belfast Research Portal