Preparation of cellulose-based sponges for wound dressing and healing

Abstract

For healing of chronic or burn wounds, polymeric sponges have been recently applied. Due to a high absorption capacity, noncitotoxicity and good swelling capabilities, for their production natural polymers are often used. In this study, macroporous regenerated cellulose was evaluated as a matrix for wound dressing materials. Active compounds, such as antibiotic neomycin and phenolic compound quercetin were immobilized in the cellulosic matrix aimed to promote wound healing process. Active compounds in the sponges were immobilized alone or with water-soluble hydroxyethylcellulose or carboxymethylcellulose. It was found that the way of preparation of sponges can affect their porosity, moisture absorption and drying rate. The best sponges for wound dressing materials were formed from freeze-dried macroporous regenerated cellulose in which was later immobilised hydroxyethylcellulose or carboxymethylcellulos with active compounds