Blackburn, G.M.

Jakeman, D.L.

Vyle, Joseph

Williams, D.M.

Williamson, M.P.

Stable bisubstrate ligands of phosphoglycerate kinase (PGK) have been synthesised with AMP or ADP conjugated to hydrolytically-stable, symmetrical analogues of 1,3-bisphosphoglycerate and their binding to yeast PGK evaluated. Their Kds decrease with net negative charge, with a penta-anionic analogue 7 showing highest affinity - in accordance with its approximation to the transition state for the reaction catalysed by PGK

Synthesis and Binding of Stable Bisubstrate Ligands for Phosphoglycerate Kinase

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