Li, Zhaozhi

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ISU ReD: Research and eData

Presentation for the Symposium on BEER November 2020Stochastic Modeling of Ovarian Follicle Growth inAdult Female RatZhaozhi Li1*, Katie Kern2, Qi Guo1, Jackson Roberts2, Natalia Toporikova, PhD2,1Department of Biology, Duke Kunshan University, Kunshan, Jiangsu, China, Duke Avenue 2153162Department of Biology, Washington and Lee University, Lexington, VA, 204 W Washington St, 24450zhaozhi.li@dukekunshan.edu.cnFolliculogenesis is the process of ovarian follicle development in female mammals. Hormone secretion andbiological molecules regulate folliculogenesis. After being recruited from follicle pool, follicles grow andsecrete estrogens. The concentration of estrogen in the ovary regulates the growth of follicles to select severaldominant follicles by size. Only the selected follicles will eventually be ovulated, while the majority of follicleswould undergo oocyte atresia and follicular depletion. The number of ovulating follicles is conserved amongspecies. However, if each follicle grows independently, why does each ovulation has a regular distance intime from the previous ovulation, a regular length, and a regular amount of follicles? The experimentalapproach to answer the question is limited by excessive cost and ethical considerations. This project offersa mathematical model to expand current understandings of the folliculogenesis process, conducted with ratovarian histology data. We first assumed an exponential distribution of initial follicle sizes, and applied themodeling framework of Lacker to simulate the effect of pituitary hormones on follicular maturation. Folliclesare ovulated when their size and the overall estrogen change rate in ovary exceed a certain threshold, which isoptimized through multiple experiments. The project also implemented two poisson distribution stochasticprocesses to simulate follicle recruitment and follicle atresia respectively. This project simulates follicularbehaviors in continuous and relatively regular reproductive periods, in which ovulating follicle numbers areconsistent, and the reproductive periods are of the same length.

Stochastic Modeling of Ovarian Follicle Growth in Adult Female Rats

https://ir.library.illinoisstate.edu/cgi/viewcontent.cgi?filename=0&article=1538&context=beer&type=additional

Stochastic Modeling of Ovarian Follicle Growth in Adult Female Rats

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