Brasic, Christine

English

ISU ReD: Research and eData

Presentation for the Symposium on BEER November 2020Testing the Effect of Acetaminophen Overdose on theLiver and the Role of Biomarkers to Predict Death orSurvivalChristine Brasic1,*, Aditi Ghosh11Department of Mathematics, University of Wisconsin Whitewater, Whitewater, WI 53190brasiccs23@uww.eduIn the United States, acetaminophen (APAP) overdose is the leading cause of acute liver injury, with a thirdof cases being unintentional. The current model for assessing liver health, The King’s College Criteria (KCC),cannot predict APAP dosage or time of overdose—crucial information for selecting treatment in the case ofAPAP overdose. The Model for APAP-Induced Liver Damage (MALD), however, uses dynamic system ofdifferential equations to model liver injury. By utilizing the three bio-markers aspartate aminotransferase,alanine aminotransferase, and international normalized ratio, MALD estimates the dose of APAP and thetime of overdose in order to assess whether treatment with N-acetylcysteine is sufficient or if survivability iscontingent on a liver transplant. These biomarkers are indicative of hepatocyte death but are not specific toAPAP. In our work we have modeled a fourth biomarker, APAP-protein adduct—specific to APAP—to theexisting model, MALD. We validated our model using 59 cases from the Acute Liver Failure Study Group.The inclusion of APAP-protein adducts in the model improved the ROC curve of MALD by 13.63%. Whenpatients with reported alcohol use were removed from the analysis, the addition of APAP-protein adductsimproved the ROC curve of MALD by 34.22%. We also performed sensitivity analysis of the importantparameters associated with the updated model. We found the addition of APAP-protein adducts increasesthe predictive quality for the model.

Testing the Effect of Acetaminophen Overdose on the Liver  and the Role of Biomarkers to Predict Death or Survival

https://ir.library.illinoisstate.edu/cgi/viewcontent.cgi?article=1450&amp;context=beer

Testing the Effect of Acetaminophen Overdose on the Liver and the Role of Biomarkers to Predict Death or Survival

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ISU ReD: Research and eData