Sordo Vieira, Luis

English

ISU ReD: Research and eData

MS1-3: A computational method for investigating theconnections between tumor associated macrophages’polarization and iron metabolismLuis Sordo Vieira1*, Joseph Masison2, Jacqueline Adams3, Adam Knapp 3, Julia Chifman3,Reinhard Laubenbacher1,41The Jackson Laboratory for Genomic Medicine, Farmington, CT 06030 2 School of Medicine, UConn Health,Farmington, CT 06030 3 Department of Mathematics and Statistics, Washington, DC 20016 4 Center forQuantitative Medicine, UConn Health, Farmington, CT 06030luis.sordovieira@jax.orgThe link between iron and cancer is still being unraveled. In several breast cancers, it has been observedthat malignant cells have a high intracellular iron content. It is believed that part of the ability of cancercells to acquire and maintain iron comes from cooperation with macrophages, the major type of phagocyticimmune cells. Interestingly, it has been observed that macrophages can serve as iron donators or as ironsequestrators, depending on the different signals they are exposed to. In order to unravel the plasticityof the iron handling of macrophages, we are developing a generalized Boolean model for the intracellularcomponents which decide the iron phenotype of macrophages. We will present our approach and somepreliminary results from our model.

A computational method for investigating the connections between tumor associated macrophages’ polarization and iron metabolism

https://ir.library.illinoisstate.edu/cgi/viewcontent.cgi?article=1334&amp;context=beer

A computational method for investigating the connections between tumor associated macrophages’ polarization and iron metabolism

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ISU ReD: Research and eData