Bosco, Giovanni

Bozler, Julianna

Kacsoh, Balint

English

ISU ReD: Research and eData

The	ability	to	integrate	experiential	information	and	recall	it	in	the	form	of	memory	is	observed	in	a	wide	range	of	taxa,	and	is	a	hallmark	of	highly	derived	nervous	systems.		Storage	of	past	experiences	is	critical	for	adaptive	behaviors	that	anticipate	both	adverse	and	positive	environmental	factors.		The	process	of	memory	formation	and	consolidation	involve	many	synchronized	biological	events	including	gene	transcription,	protein	modification,	and	intracellular	trafficking:		However,	many	of	these	molecular	mechanisms	remain	illusive.		With	Drosophila	as	a	model	system	we	use	a	nonassociative	memory	paradigm	and	a	systems	level	approach	to	uncover	novel	transcriptional	patterns.		RNA	sequencing	of	Drosophila	heads	during	and	after	memory	formation	identified	a	number	of	novel	memory	genes.	Tracking	the	dynamic	expression	of	these	genes	over	time	revealed	complex	gene	networks	involved	in	long	term	memory.		In	particular,	this	study	focuses	on	two	functional	gene	clusters	of	signal	peptides	and	proteases.		Bioinformatics	network	analysis	and	prediction	in	combination	with	high-throughput	RNA	sequencing	identified	previously	unknown	memory	genes,	which	when	genetically	knocked	down	resulted	in	behaviorally	validated	memory	defects.		

A systems level approach to temporal expression dynamics in Drosophila reveals clusters of long term memory genes

https://ir.library.illinoisstate.edu/cgi/viewcontent.cgi?article=1164&amp;context=beer

A systems level approach to temporal expression dynamics in Drosophila reveals clusters of long term memory genes

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