Ciocanel, Maria-Veronica

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ISU ReD: Research and eData

Modeling microtubule-based transportin the frog egg cellAuthors:Maria-Veronica Ciocanel∗, Division of Applied Mathematics, Brown University,Email: veronica_ciocanel@brown.edu.Bjo¨rn Sandstede, Division of Applied Mathematics, Brown University,Email: bjorn_sandstede@brown.edu.Kimberly Mowry, Department of Molecular Biology, Cell Biology, and Biochemistry, BrownUniversity,Email: kimberly_mowry@brown.edu.Abstract:In the development of egg cells into embryos, spatial differentiation is essential in determiningthe role of the new embryo cells in the growing organism. This spatial patterning often relieson asymmetric accumulations and transport of proteins in the egg cell. In the frog, messengerRNA (mRNA) dynamically switches between diffusion and active transport states in itsjourney to the periphery of the egg cell, where it accumulates and creates a spatial axis ofdevelopment. Using dynamical systems modeling and analysis, we investigate the transportof mRNA and its dependence on cytoskeleton roads in the egg cells called microtubules.Numerical studies using model microtubule structures allow us to predict that an anchoringmechanism at the cell periphery may be key in healthy development.

Modeling microtubule-based transport in the frog egg cell

https://ir.library.illinoisstate.edu/cgi/viewcontent.cgi?article=1131&amp;context=beer

Modeling microtubule-based transport in the frog egg cell

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ISU ReD: Research and eData