Lewis, Owen

ISU ReD: Research and eData

Maintenance of the pH gradient in the gastricmucus layerOwen L. LewisThe gastric mucus is a complex gel-like layer of various proteins and solutescoating the epithelial surface of the stomach. This layer is widely recognized toserve a protective function, shielding the epithelium and the rest of the gastricmucosa from the extremely low pH and digestive enzymes present in the stomachlumen. Often described as a “diffusion barrier” the mucus layer is thought tohinder the transport of diffusive species from the lumen, to the stomach wall.However, there is still a lack of consensus on the mechanism by which themucus layer hinders lumen-to-wall transport while allowing acid and enzymessecreted from the mucosa unimpeded transport to the lumen. Using a model oftwo-phase fluid motion coupled with electro-diffusion, we test one hypothesis.Furthermore, we explore what regulatory mechanisms are necessary to segregatean acidic stomach lumen from a pH neutral stomach wall.1

Maintenance of the pH gradient in the gastric mucus layer.

http://ir.library.illinoisstate.edu/cgi/viewcontent.cgi?article=1067&context=beer

Maintenance of the pH gradient in the gastric mucus layer.

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ISU ReD: Research and eData