Ingestible electronics have revolutionized the standard of care for a variety of health conditions. Extending the capacity and safety of these devices, and reducing the costs of powering them, could enable broad deployment of prolonged-monitoring systems for patients. Although previous biocompatible power-harvesting systems for in vivo use have demonstrated short (minute-long) bursts of power from the stomach, little is known about the potential for powering electronics in the longer term and throughout the gastrointestinal tract. Here, we report the design and operation of an energy-harvesting galvanic cell for continuous in vivo temperature sensing and wireless communication. The device delivered an average power of 0.23 μW mm⁻² of electrode area for an average of 6.1 days of temperature measurements in the gastrointestinal tract of pigs. This power-harvesting cell could provide power to the next generation of ingestible electronic devices for prolonged periods of time inside the gastrointestinal tract.National Institutes of Health (U.S.) (Grant EB-000244
