This paper proposes an environment devoted to simulate the use of autonomous systems in the context of space exploratory missions and
operations; this research focuses on supporting engineering of autonomous systems and of their innovative artificial intelligences through
interoperable simulation. The proposed approach enables also development of training and educational solutions for use of robots and autonomous systems in space critical environments. The paper addresses different application areas including robotic inventory and
warehouse solutions, intelligent space guard systems, drones for supporting extravehicular activities and for managing accidents and health
emergencies. The paper investigates the potential of autonomous systems as well as their capability to interoperate with other systems and with
humans, especially in critical environments. Finally, the paper presents the existing researches for interoperable simulators devoted to address
these challenging topics within Simulation Exploratory Experience initiative