The paper proposes an open architecture to support the creation of a synthetic environment devoted to simulate complex scenarios related to the protection of cyber-physical systems. The proposed approach is based on applying the combination of interoperable simulation and serious games to develop a framework where different models, as well as real equipment, could interoperate based on High Level Architecture standard. By this approach, it becomes possible to create a federation reproducing a scenario including multiple physical and cyber layers interacting dynamically and reproducing complex situations. The authors propose an example of specific case study conceptually developed to apply this approach
