Ajikumar, Parayil Kumaran

Bauwens, David

Biggs, Bradley Walter

Coussement, Pieter

De Bruyn, Frederik

De Mey, Marjan

De Paepe, Brecht

Lim, Chin Giaw

Maertens, Jo

Philippe, Ryan

Van Brempt, Maarten

Ghent University Academic Bibliography

Microbial cell factories for the production of specialised plant metabolites 	Frederik	De	Bruyn	a,	Maarten	Van	Brempt	a,	Brecht	De	Paepe	a,	 Jo	Maertens	a,	David	Bauwens	a,	Pieter	 Coussement	 a,	 Chin	 Giaw	 Limb,	 Bradley	 Walter	 Biggsb,	 Ryan	 Philippeb,	 Parayil	 Kumaran	Ajikumarb,	Marjan	De	Mey	a	 a Centre for Synthetic Biology, Ghent University, Coupure Links 653, B9000 Ghent, Belgium (marjan.demey@ugent.be) b Manus Biosynthesis, 1030 Massachusetts Avenue, Suite 300, Cambridge, MA 02138, USA  Specialised plant metabolites have valuable bioactive properties for human health care. Traditional production methods are time consuming, create a vast amount of waste and are dependent on uncertain external factors. Micro-organisms as producers of these metabolites are a very promising alternative, as they allow production on an industrial scale with better control on wastage, etc.  The chemical diversity in specialised plant metabolites often comes from a series of chemical processes. The specialised plant metabolite pathway taps into the primary metabolism at specific building blocks to generate scaffolds. After scaffold creation, tailoring enzymes will decorate these scaffolds with various functional moieties, effectively multiplying total potential diversity. A level of hierarchy exists among functionalisations, with oxygenation and glycosylation playing a preeminent role.  Here we show the development of an E. coli platform for the production of specialised plant metabolites through metabolic engineering and synthetic biology.   Acknowledgement: Frederik De Bruyn and Pieter Coussement were supported by a fellowship of the Institute for the Promotion of Innovation through Science and Technology in Flanders (IWT-Vlaanderen).  ---------------------------------------------------------------------	Preferred	session:	Systems	and	Synthetic	Biology	of	Terpenoids		

Microbial cell factories for the production of specialised plant metabolites

https://biblio.ugent.be/publication/8526774/file/8528748

Microbial cell factories for the production of specialised plant metabolites

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Ghent University Academic Bibliography