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Osteointegration of porous poly-ε-caprolactone-coated and previtalised magnesium implants in critically sized calvarial bone defects in the mouse model
Authors
Hugo Murua Escobar
Nils-Claudius Gellrich
+10 more
Michael Grau
Heinz Haferkamp
Matthias Lüpke
Julia Matena
Ingo Nolte
Laura Roland
Hermann Seifert
Christian Seiler
Michael Teske
Claudia Windhövel
Publication date
1 January 2017
Publisher
Basel : MDPI AG
Doi
Cite
Abstract
Metallic biomaterials are widely used in maxillofacial surgery. While titanium is presumed to be the gold standard, magnesium-based implants are a current topic of interest and investigation due to their biocompatible, osteoconductive and degradable properties. This study investigates the effects of poly-ε-caprolactone-coated and previtalised magnesium implants on osteointegration within murine calvarial bone defects: After setting a 3 mm × 3 mm defect into the calvaria of 40 BALB/c mice the animals were treated with poly-ε-caprolactone-coated porous magnesium implants (without previtalisation or previtalised with either osteoblasts or adipose derived mesenchymal stem cells), porous Ti6Al4V implants or without any implant. To evaluate bone formation and implant degradation, micro-computertomographic scans were performed at day 0, 28, 56 and 84 after surgery. Additionally, histological thin sections were prepared and evaluated histomorphometrically. The outcomes revealed no significant differences within the differently treated groups regarding bone formation and the amount of osteoid. While the implant degradation resulted in implant shifting, both implant geometry and previtalisation appeared to have positive effects on vascularisation. Although adjustments in degradation behaviour and implant fixation are indicated, this study still considers magnesium as a promising alternative to titanium-based implants in maxillofacial surgery in future. © 2017 by the authors
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Multidisciplinary Digital Publishing Institute
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Institutionelles Repositorium der Leibniz Universität Hannover
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