Objective:To investigate the chemical constituents of Scutellaria galericulata.Method: The herb of S.galericulata was crushed and then extracted with 95% ethanol.The extracts were combined and concentrated under reduced pressure.The extracts were dispersed in water and respectively extracted with petroleum ether, ethyl acetate, chloroform and n-butanol to get petroleum ether fraction, ethyl acetate fraction, chloroform fraction and n-butanolfraction.Ethyl acetate fraction were separated and purified by silica gel column chromatography, Sephadex LH-20 and HPTLC.The structures of the glycosides compounds were identified by their physico-chemical properties and spectral data.Result: Eleven compounds were isolated and purified as: isocrenatoside (1),osmanthuside B_6 (2), eutigoide A (3), plantainoside C (4), calceorioside B (5), isomartynoside (6), verbascoside (7), acteoside (8), desrhamnosyl acteoside (9), 5,7-dihydroxy-8,2'-dimethoxyflavone-7-O-beta-D-glucopyranoside (10), and apigenin-7-O-rhamnoside (11).Conclusion: Compounds 1-4 and 7-11 were isolated from S.galericulata for the first time, and the literature review showed that plantainoside C, apigenin-7-O-rhamnoside and other compounds had anti-inflammatory and antioxidant activities, providing a good reference for further studies onpharmacodynamic material basis and the development and utilization of S.galericulata
