A. Kolmogorov

Alessandro de Moura

Conrad A. Nieduszynski

J. Lygeros

Renata Retkute

S. C.-H. Yang

English

PubMed

Eukaryotic DNA replication is initiated from multiple sites on the chromosome, but little is known about the global and local regulation of replication. We present a mathematical model for the spatial dynamics of DNA replication, which offers insight into the kinetics of replication in different types of organisms. Most biological experiments involve average quantities over large cell populations (typically >107 cells) and therefore can mask the cell-to-cell variability present in the system. Although the model is formulated in terms of a population of cells, using mathematical analysis we show that one can obtain signatures of stochasticity in individual cells from averaged quantities. This work generalizes the result by Retkute et al. [Phys. Rev. Lett. 107, 068103 (2011)] to a broader set of parameter regimes

Retkute, Renata

Nieduszynski, Conrad A.

Moura, Alessandro de

Name not available

Mathematical modeling of genome replication

Nottingham eTheses

Eukaryotic DNA replication is initiated from multiple sites on the chromosome, but little is known about the global and local regulation of replication. We present a mathematical model for the spatial dynamics of DNA replication, which offers insight into the kinetics of replication in different types of organisms. Most biological experiments involve average quantities over large cell populations (typically >107 cells) and therefore can mask the cell-to-cell variability present in the system. Although the model is formulated in terms of a population of cells, using mathematical analysis we show that one can obtain signatures of stochasticity in individual cells from averaged quantities. This work generalizes the result by Retkute et al. to a broader set of parameter regimes

De Moura, Alessandro

University of East Anglia digital repository

Nottingham ePrints

Crossref

Physical Review E

Repository@Nottingham

https://nottingham-repository.worktribe.com/1009203/1/Conrad_Nieduszynski--Mathematical_modeling.pdf

Mathematical modeling of genome replication

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Name not available

Nottingham eTheses

Name not available

University of East Anglia digital repository

Nottingham ePrints

Crossref

Repository@Nottingham