[This corrects the article DOI: 10.1371/journal.pone.0215405.

Barkmann, Reinhard

Bergh, J. P. van den

Glüer, Claus C.

Gräsel, Melanie

Heyer, Frans

Iori, Gianluca

Pahr, Dieter

Peralta, Laura

Raum, Kay

Reisinger, Andreas

Schneider, Johannes

Wyers, Caroline

PLoS ONE

English

Institutional Repository of the Freie Universität Berlin

CORRECTIONCorrection: Large cortical bone pores in thetibia are associated with proximal femurstrengthGianluca Iori, Johannes Schneider, Andreas Reisinger, Frans Heyer, Laura Peralta,Caroline Wyers, Melanie Gra¨sel, Reinhard Barkmann, Claus C. Glu¨er, J. P. van den Bergh,Dieter Pahr, Kay RaumThere are errors in Tables 1 and 3. Please see the correct Tables 1 and 3 here.PLOS ONE | https://doi.org/10.1371/journal.pone.0219443 July 5, 2019 1 / 3a1111111111a1111111111a1111111111a1111111111a1111111111OPEN ACCESSCitation: Iori G, Schneider J, Reisinger A, Heyer F,Peralta L, Wyers C, et al. (2019) Correction: Largecortical bone pores in the tibia are associated withproximal femur strength. PLoS ONE 14(7):e0219443. https://doi.org/10.1371/journal.pone.0219443Published: July 5, 2019Copyright: © 2019 Iori et al. This is an open accessarticle distributed under the terms of the CreativeCommons Attribution License, which permitsunrestricted use, distribution, and reproduction inany medium, provided the original author andsource are credited.Table 1. Bone properties of the tibia midshaft measured with microCT and SAM.Name Unit DescriptionmicroCTvBMDtot Bone mineral density [mgHA/cm3] Of the entire bonevBMDcort Of the cortical boneSAMTt.Ar Total area [mm2] Area occupied by the bone cross sectionCt.Ar Cortical area [mm2] Area of cortical boneT.Ar Tissue area [mm2] Area of the bone tissueCt.Wba Areal portion of cortical tissue [%] Cortical tissue area / Tt.ArCt.Th Cortical thickness [mm] Most frequent minimum distancebetween peri- and endosteal surfacesCt.Po Cortical porosity [%] 100 × (1 –tissue pixels / cortical bone pixels)Po.D Pore density [#/mm2] Number of pores per square mmrelPo.n60µm Prevalence oflarge pores[%] Number of pores with diameter larger than a fixed threshold divided by total number of poresPo.Dm Pore diameter [µm] Diameter of the largest inscribed circle [20]Po.Dm10% Po.Dm quantiles [µm] Quantiles of the Po.Dm distributionrelCt.Po60µm Relative proportion of porosity [%] Proportion of porosity due to pores with diameter above fixed thresholdhttps://doi.org/10.1371/journal.pone.0219443.t001Table 3. Hip DXA, macroscopic geometry and vBMD of the tibia midshaft, architecture and composition of tibial cortical bone.control for aBMDneckSTANCE FALL STANCE FALLaBMDneck hvFE_S hvFE_Fu hvFE_S hvFE_Fu hvFE_S hvFE_Fu hvFE_S hvFE_FuMean ± SD (min-max) CV [%] Pearson rLeft hip (n = 19)DXAaBMDneck [mgHA/cm2] 529 ± 96 (404–760) 18 / 0.62�0.74��0,66�0,78��/ / / /Left tibia (n = 19)MicroCT (whole cross section)vBMDtot [mgHA/cm3] 617 ± 133 (261–776) 22 0.46 0.69�0.65�0.58 0.52vBMDcort [mgHA/cm3] 914 ± 54 (801–988) 6 0.72��0.63�0.65�0.53SD(vBMDcort) [mgHA/cm3] 185 ± 36 (131–266) 19 -0.66�-0.59�-0.62�-0.54SAM (whole cross section)Tt.Ar [mm2] 441 ± 110 (326–829) 26Ct.Ar [mm2] 238 ± 65 (77–349) 25 0.51 0.59�0.71��0,58 0,60�0.58T.Ar [mm2] 235 ± 59 (96–333) 22 0.47 0.52 0.67�0,57 0,60�0.55Ct.Wba [%] 49.1 ± 14.5 (15.6–69.8) 27 0.51 0.76��0.73��0,48 0.65�0.61�SAM (ROIUS)Ct.Th [mm] 2.98 ± 1.19 (0.82–5.35) 40 0.75��0.66�0.81��0,77��0,81��0.57 0.56 0.54Ct.Po [%] 11.1 ± 3.6 (7.7–21.4) 32Po.D [1/mm2] 16.9 ± 1.8 (13.2–21.1) 11Po.D60µm [1/mm2] 4.5 ± 1.1 (2.8–6.2) 25Po.D100µm [1/mm2] 1.3 ± 0.7 (0.5–3.4) 56 -0.54 -0.56 -0.52Po.D160µm [1/mm2] 0.3 ± 0.3 (0.1–1.4) 94 -0.52 -0.52 -0.49 -0.54relPo.n60µm [%] 27.9 ± 6.7 (18.0–38.4) 24relPo.n100µm [%] 7.6 ± 4.3 (2.5–20.9) 56 -0.53 -0.57 -0.47 -0.56(Continued)PLOS ONE | https://doi.org/10.1371/journal.pone.0219443 July 5, 2019 2 / 3Reference1. Iori G, Schneider J, Reisinger A, Heyer F, Peralta L, Wyers C, et al. (2019) Large cortical bone pores inthe tibia are associated with proximal femur strength. PLoS ONE 14(4): e0215405. https://doi.org/10.1371/journal.pone.0215405 PMID: 30995279Table 3. (Continued)control for aBMDneckSTANCE FALL STANCE FALLaBMDneck hvFE_S hvFE_Fu hvFE_S hvFE_Fu hvFE_S hvFE_Fu hvFE_S hvFE_FurelPo.n160µm [%] 1.9 ± 1.8 (0.4–8.5) 96 -0.51 -0.52 -0.49 -0.56Po.Dm [µm] 51 ± 6 (44–67) 12 -0.47 ns nsSD(Po.Dm) [µm] 34 ± 7 (23–55) 21 -0.55 -0.57 -0.52 -0.60�Po.Dm10% [µm] 19 ± 4 (12–25) 20Po.Dm90% [µm] 91 ± 19 (68–152) 21 -0.49 -0.54 -0.51Ct.Po60µm [%] 7.9 ± 3.6 (4.5–18.9) 46 -0.46 -0.50 -0.48Ct.Po100µm [%] 4.8 ± 3.5 (1.5–16.4) 73 -0.50 -0.52 -0.51Ct.Po160µm [%] 2.4 ± 2.6 (0.4–11.4) 107 -0.47 -0.50relCt.Po60µm [%] 68.9 ± 8.6 (54.8–88.3) 13 -0.51 -0.60�-0,49 -0,50 -0.60�relCt.Po100µm [%] 40.1 ± 13.9 (17.3–77.0) 35 -0.61�-0.63�-0,46 -0,48 -0.54 -0.62�relCt.Po160µm [%] 18.9 ± 12.1 (5.1–53.6) 64 -0.50 -0.53 -0.54The last nine columns show the Pearson coefficients of the linear correlation with aBMDneck, hvFE_S and hvFE_Fu and the Pearson r of the linear partial correlationanalysis controlling for the effect of aBMDneck, for both STANCE and FALL loading conditions. Coefficients are reported only for p-values< 0.05. The 95% ConfidenceIntervals for the correlation coefficients of this table can be found in S3 Table.� p < 0.01;�� p < 0.001.https://doi.org/10.1371/journal.pone.0219443.t002PLOS ONE | https://doi.org/10.1371/journal.pone.0219443 July 5, 2019 3 / 3

Correction: Large cortical bone pores in the tibia are associated with proximal femur strength

[This corrects the article DOI: 10.1371/journal.pone.0215405.]

Gianluca Iori

Johannes Schneider

Andreas Reisinger

Frans Heyer

Laura Peralta

Caroline Wyers

Melanie Gräsel

Reinhard Barkmann

Claus C Glüer

J P van den Bergh

Dieter Pahr

Kay Raum

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Correction: Large cortical bone pores in the tibia are associated with proximal femur strength.

https://refubium.fu-berlin.de/bitstream/fub188/28117/1/2019_Iori_etal.pdf

Correction: Large cortical bone pores in the tibia are associated with proximal femur strength

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