This paper was presented at the 3rd Micro and Nano Flows Conference (MNF2011), which was held at the Makedonia Palace Hotel, Thessaloniki in Greece. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, Aristotle University of Thessaloniki, University of Thessaly, IPEM, the Process Intensification Network, the Institution of Mechanical Engineers, the Heat Transfer Society, HEXAG - the Heat Exchange Action Group, and the Energy Institute.This paper presents the experimental results of determining friction factors for two microchannels with circular cross-sections: rectilinear and curvilinear. The inner diameter of the channels is 68.9 and 70.3 μm. The Reynolds numbers ranged from 320 to 3215. Pressure measurements are carried out simultaneously in 16 locations along the straight microchannel and in 12 locations for the curved microchannel. The friction factor for the straight microchannel is in good agreement with the theoretical value for the round smooth tubes. For the curved microchannel, the friction factor value of the curved section is less than the reference value for smoothly curved tubes. The Reynolds number for the laminar-turbulent transition in a straight microchannel is 2300–2600. In the curved microchannel the transition is not observed. The length of the developing region was identified, and the inlet minor loss coefficient is calculated.This work was supported by the Siberian Branch of the Russian Academy of Sciences (integration project of SB RAS no. 110)