A simple approach towards efficient artificial proteases based on the cyclen
ligand is presented. We thus achieved an increase of the proteolytic activity
of two orders of magnitude when compared to the unsubstituted cyclen complex.
Amphiphilic Cu(II) and Co(III) complexes cut BSA and myoglobin as model
substrates at μM concentrations. MALDI-ToF MS is used to identify the cleavage
fragments
