Background In order to provide new knowledge on the storage of strontium (Sr),
barium (Ba), cadmium (Cd), copper (Cu), zinc (Zn), manganese (Mn), chromium
(Cr), antimony (Sb), selenium (Se) and lead (Pb) in the feline organism, we
measured the concentrations of these elements in the liver, renal cortex and
renal medulla, evaluating also the impact of age, sex or the occurrence of a
chronic kidney disease (CKD). The element concentrations in the tissues of 47
cats (22 male; 25 female; aged between 2 months and 18 years) were measured
using inductively coupled plasma mass spectrometry. Results Cu, Zn and Mn were
the highest in the liver, followed by the renal cortex and the renal medulla.
The Cd concentrations were lower in the renal medulla compared to the renal
cortex and the liver, and Sr was higher in the renal medulla compared to the
liver. The Se concentrations in the cortex of the kidneys were higher than in
the medulla of the kidneys and in the liver. Higher Cd concentrations were
measured in the renal cortex of female cats, while no further gender-related
differences were observed. Except for Cr, Sb and Se, age-dependencies were
detected for the storage of all elements. The occurrence of a CKD also
affected the storage of the elements, with lower concentrations of Ba (renal
medulla), Zn (renal cortex; renal medulla) and Mn (liver; renal medulla), but
higher Cd concentrations (liver; renal cortex) in diseased cats. Conclusions
In conclusion, the present results provide new information on the accumulation
of specific elements in the feline liver and kidneys, demonstrating a
dependency on age and an impaired kidney function, but not on the sex of the
animals