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Study on Correlation of Depression of Liver Depression and Spleen Deficiency Syndrome with SIRT1/PGC-1α Pathway
Authors
于姚
李阳
+3 more
袁清洁
郭建友
郭蓉娟
Publication date
1 January 2020
Publisher
Abstract
【目的】探究抑郁症肝郁脾虚证是否会出现SIRT1/PGC-1α通路的异常。【方法】纳入健康人(平和质)、肝气郁结型抑郁症患者和肝郁脾虚型抑郁症患者各10例,采集外周血以Western Blot法检测3组受试者的沉默信息调节因子1(SIRT1)、过氧化物酶体增殖物激活受体-γ共激活因子1α(PGC-1α)、核呼吸因子1(NRF-1)、核呼吸因子2(NRF-2)、线粒体转录因子A(TFAM)蛋白表达含量。【结果】与健康人组相比,肝气郁结型抑郁症组患者外周血SIRT1蛋白表达量显著升高(P<0.05),肝郁脾虚型抑郁症组患者外周血SIRT1、PGC-1α、TFAM蛋白表达量显著降低(P<0.05)。【结论】SIRT1/PGC-1α通路介导的线粒体能量代谢及生物合成异常可能是抑郁症肝郁脾虚证的生物学实质之一。</p
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Last time updated on 18/12/2020