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Mechanism of gut barrier injury and bacterial translocation in anxiety-depression induced degenerative neurosis
Authors
凌燕
吕艳霞
+3 more
杨路
禤宇明
董婷婷
Publication date
1 January 2020
Publisher
Doi
Cite
Abstract
肠道屏障是脑-肠道交互作用的晴雨表。健全的肠道屏障对于维系肠道内微生态,抵御外源性病原体的侵入至关重要。焦虑抑郁症能够损害肠道屏障,破坏肠道菌群平衡。肠道屏障损伤引起肠道渗透性升高,肠腔细菌移位,促使外源性病原体进入血液循环和神经系统,启动系统性炎症反应。炎症反应对脑神经的损伤是诱导阿尔茨海默病和帕金森症发生、发展的主要原因。肠道屏障损伤还会破坏原有的肠道菌群结构,造成肠道菌群失调,不仅进一步损伤肠道屏障,还影响神经组织的结构和功能,是阿尔茨海默病和帕金森症形成的另一因素。此综述依据近年来的相关研究,从肠道屏障损伤的角度阐述了焦虑抑郁症触发退行性神经症的机制,强调维护肠道屏障功能在预防退行性神经疾病中具有重要的临床意义
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Institutional Repository of Institute of Psychology, Chinese Academy of Sciences
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oai:ir.psych.ac.cn:311026/3203...
Last time updated on 16/09/2020
Institutional Repository of Institute of Psychology, Chinese Academy of Sciences
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:ir.psych.ac.cn:311026/3203...
Last time updated on 16/09/2020
Institutional Repository of Institute of Psychology, Chinese Academy of Sciences
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:ir.psych.ac.cn:311026/3720...
Last time updated on 30/04/2021