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The Protective Role of the Hsp70 in Hippocampal CA3 Neurons against Chronic Psychological Stress
Authors
亓晓丽
姚树桥
彭敏
朱熊兆
Publication date
1 January 2006
Publisher
Abstract
目的:探讨心理应激对海马CA3区神经元凋亡的影响,热休克蛋白70(Hsp70)对心理应激引起的海马CA3区神经元凋亡的保护作用。方法:建立心理应激、热应激(Heat Shock Pretreatment)、心理应激加热应激三种动物模型,利用免疫组化和TUNEL分别检测海马CA3区神经元在第1、2、3个月三个时间段的Hsp70表达和神经元凋亡水平。结果:有心理应激的各组动物海马凋亡神经元数高对照组(P<0·05),热应激加心理应激组凋亡神经元在2、3个月时较同时段心理应激组下降(P<0·05),但热应激组与对照组间差异没有显著性。有热应激各组Hsp70表达数高于无热应激的两组(P<0·01)。海马CA3区Hsp70表达水平与神经元调亡水平呈负相关(r=-0·26,P=0·03)。结论:热应激可促进海马Hsp70的表达,热休克蛋白70对心理应激导致的海马CA3区神经元损伤有保护作用
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Institute of Psychology,Chinese Academy Of Sciences
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oai:ir.psych.ac.cn:311026/3183
Last time updated on 08/08/2019
Institutional Repository of Institute of Psychology, Chinese Academy of Sciences
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Last time updated on 05/01/2021
Institutional Repository of Institute of Psychology, Chinese Academy of Sciences
See this paper in CORE
Go to the repository landing page
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oai:ir.psych.ac.cn:311026/3182
Last time updated on 25/07/2018