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中国毒理学会会议论文集
Authors
刘丽京
孙成玉
+14 more
孟适秋
张若曦
徐凌志
徐德峰
朱维莉
李素霞
温泉
薛言学
袁铭
赵媚
邓佳慧
陆林
韩颖
高雪娇
Publication date
1 November 2016
Publisher
Abstract
目的:通过慢性应激模型和药理学手段研究NR2B亚基在抑郁症发病中的作用,选择性拮抗NR2B亚基的快速抗抑郁样作用及其神经生物学机制。方法:采用大鼠慢性应激抑郁模型,通过核团微注射方法研究内侧前额叶皮层内谷氨酸能NMDA受体不同亚基功能与抑郁样行为的关系。通过微透析技术及Western blot方法来检测内侧前额叶皮层内谷氨酸水平及相关分子的变化;通过多个抑郁模型及多种行为学测试(包括强迫游泳测试, </p
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Last time updated on 31/03/2018