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research
Serial changes in cardiovascular and renal function of rabbits ingesting a high-fat, high-calorie diet
Authors
Vladan Antic
Jean-Pierre Montani
Aldo Tempini
Publication date
2 August 2017
Publisher
Abstract
To explore the mechanisms of obesity-induced hypertension we analyzed the sequential changes in cardiovascular and renal function in adult rabbits switched to high-fat diet (HFD) for 8 weeks. Animals were housed in metabolic cages for continuous 24-h recording of arterial pressure by telemetry and daily urine collection. High-fat diet induced a progressive increase in body weight (+47%) and a rapid rise in mean arterial pressure, heart rate, and glomerular filtration rate that stabilized, respectively, at 14%, 31% and 68% greater than control values. Time-course analysis of changes in blood pressure may reveal two components of obesity-induced hypertension, an early phase related to HFD itself and a later phase related to weight gain. Am J Hypertens 1999;12:826-829 © 1999 American Journal of Hypertension, Lt
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oai:CiteSeerX.psu:10.1.1.972.7...
Last time updated on 02/11/2017
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