Iako su se pedijatrijska kardiologija i reumatologija unatrag deset godina i u našim uvjetima formalno
razdvojile, među njima su ostale snažne poveznice. One se više ne očituju samo u reumatskoj vrućici već i u drugim
reumatološkim entitetima: sistemskom eritemskom lupusu, antifosfolipidnom sindromu, sistemskoj sklerodermiji,
Kawasakijevoj bolesti, nodoznom poliarteritisu, nekim oblicima granulomatoznog vaskulitisa. Posebno se osvrćemo
na pojavu kompletnoga kongenitalnog atrioventrikularnog bloka (CCAVB) u trudnica koje zbog sistemskih bolesti
vezivnog tkiva imaju osobita ANA-protutijela (anti-SSA/Ro i/ili anti-SSB/La), ali i vjerojatnost da istovjetno upalno
zbivanje u srcu bude razlogom razvoja restrikcijske kardiomiopatije pridružene CCAVC-u. Iako je time reumatologija
već odavno ušla u ranu fetalnu dob, postoje i neki problemi koji se odnose na embrionalno razdoblje (utjecaj odnosa
metotreksata i folne kiseline na embrionalni razvoj srca) i na kasno fetalno razdoblje (zbog odnosa antiprostaglandinskih
antifl ogistika na prematurno zatvaranje Botallova duktusa). U radu se posebno osvrćemo na najtežu komplikaciju
u fetalnom razdoblju koja se zove neonatalni lupusni sindrom. Time se ostvaruje višestruka veza između kardiologije
i reumatologije svih dobnih skupina, od embrionalne i fetalne do odrasle dobi. Upravo i jest cilj ovoga rada prikazati
neke važne poveznice i na taj način aktualizirati novu suradnju pedijatrijske kardiologije s reumatologijom od fetalne
do odrasle dobi.Even though in the last ten years pediatric cardiology and rheumatology have formally separated in
Croatia as well, strong links still remain between them. Th ey are no longer manifested through rheumatic fever, but
through other rheumatic entities: systemic lupus erythematosus, antiphospholipid syndrome, systemic scleroderma,
Kawasaki disease, polyarteritis nodosa, and some forms of granulomatous vasculitis. We take special note of the occurrence
of complete congenital atrioventricular block (CCAVB) in pregnant women who, due to systemic connective
tissue diseases, develop distinctive ANA antibodies (anti-SSA/Ro and/or anti SSB/La), but who are also likely to have
the same infl ammation within the heart, leading to the development of restricted cardiomyopathy associated with
CCAVC. Although rheumatology has thus been involved with early fetal age for some time now, there are also some
issues relating to the embryonal stage (the association between methotrexate/folic acid and heart development in embryos),
as well as to the late fetal stage (antiprostaglandin anti-infl ammatory agent impact on premature ductus arteriosus
closure). We gave special attention to the neonatal lupus syndrome, the most serious complication in the fetal
period. Th us the multiple association between cardiology and rheumatology in all age groups, from the embryonal and
fetal stage to adulthood, is being realized. Th e aim of this paper is to present some important links and thus further
emphasize the new cooperation between pediatric cardiology and rheumatology from fetal stage to adulthood
