Bolesnici s upalnim autoimunim reumatskim bolestima
imaju povećan rizik od obolijevanja od malignih bolesti,
uključujući limfoproliferativne sindrome i leukemije,
osobito oni s reumatoidnim artritisom, sistemskim
lupusom, Sjögrenovim sindromom, dermatomiozitisom
i sistemskom sklerozom. Povećana učestalost malignih
bolesti dovodi se u vezu s autoimunošću, kroničnom
upalnom aktivnošću, ali i imunomodulatornom i imunosupresivnom terapijom. Reumatske tegobe mogu
biti dio slike paraneoplastičkog sindroma što dodatno
utječe na diferencijalnu dijagnozu, praćenje tijeka bolesti
i izbor terapije uz procjenu individualnog rizika i utjecaja
okolišnih čimbenika.Patients with inflammatory autoimmune rheumatic diseases,
especially those with rheumatoid arthritis, systemic lupus
erythematosus, Sjögren’s syndrome, dermatomyositis,
and systemic sclerosis, are at increased risk of malignancies,
including leukemia and lymphoproliferative syndromes.
An increased incidence of malignant disease is associated
with autoimmunity, chronic inflammatory activity,
as well as immunomodulatory and immunosuppressive therapy. Rheumatic manifestations can be part of paraneoplastic
syndrome, which may further affect the differential
diagnosis, disease monitoring, or treatment strategies
along with the assessment of individual risks and the impact
of environmental factors
