Garlic tuber is proved decreasing blood pressure. The research on formulation of garlic extract tablet using Avicel PH 101 as disintegrant and the tablets physical characteristic has been conducted. Garlic extract is prepared by maceration with ethanol 96% as solvent. Tablet of garlic extract is made by wet granulation method with weight of tablet 600 mg each. Tablet of garlic extract is made in three formulas with varied Avicel PH 101 as disintegrant, they are Formula 1 (7.5%), Formula II (10%), and Formula III (12.5%). The obtained granule is tested the flow rate whereas tablets are examined the physical characteristic (weight uniformity, hardness, brittleness, and disintegration time). The results shows that Avicel PH 101 can be used as disintegrant of garlic extract tablet with concentration 7.5 – 12.5%. The higher Avicel PH 101 concentration will decrease granule flow rate and tablet hardness, increase brittleness and fasten disintegration time.
Key words: garlic, Avicel PH 101, tablet, wet granulation
