: Chronic kidney disease is a pathophysiology process with various etiology, causing a progressive decline on kidney function, and in general ends with kidney failure (stage 5). For the last forty years, creatinine serum had been the most common and affordable detection serum to measure kidney performance. The amount of creatinine serum is increased on non-dialysis chronic kidney disease patients. Approximately, 57% of non-dialysis chronic kidney disease patients have 7-12 mg/dL creatinine level. Research objective: To understand the description of creatinine serum level on non-dialysis chronic kidney disease patients. Research method: Cross sectional descriptive, to obtain the data of creatinine serum on non-dialysis chronic kidney disease patients carried out on December 2015 – January 2016 at two hospitals, which are RSUP. Prof. Dr. R. D. Kandou Manado and Rumah Sakit Advent Manado. The research sample were the blood sample from 35 people suffering a stage five non dialysis chronic kidney disease, which determined by consecutive sampling from non-probability sampling model. Result: Based on the laboratory result, the 35 patients diagnosed with a stage five non dialysis chronic kidney disease are undergoing an increase on creatinine serum (100%). Conclusion: Based on the research result, it can be concluded that the increase of creatinine level is occurred on stage five non dialysis chronic kidney disease patients