: Therapeutic communication is communication that is planed and carried to asmed to help the healing and recovery of the patient. Anxiety is a fear that is not pleasant and can not be justified, often accompanied by physiological symptions. The purpose to test the therapeutic nurse respondents. The result based on test spearman rho correlation therapeutic communication with value obtained in levels of anxiety (p) = 0,000 where the value of α = 0,817. Conclution of this during infusion in children in the departemen of RSUP Prof.Dr.R.D.Kandou Manado