Leukopenia Sebagai Prediktor Terjadinya Sindrom Syok Dengue Pada Anak Dengan Demam Berdarah Dengue Di Rspi. Prof. Dr. Sulianti Saroso

Abstract

The development of DHF patient usually assessed base on clinical condition, platelet count and haematocrit value as the DSS indicators. While leukocyte count is irrespective though leucopenia is common in viral infection. Therefore, further analysis was run to determine whether leucopenia could be as a predictor of DSS This study was a retrospective study with a case control (1:2) design using hospitalized children medical records from January 2006 to April 2008 at Prof. Dr. Sulianti Saroso Infectious Diseases Hospital. DSS cases were purposive sampling, and DHF controls were selected using simple random sampling. There were 43 children diagnosed as DSS, and 86 diagnosed as DHF. By multivariate analysis, DHF subjects with leucopenia showed 2.9 times higher risk to develop DSS than DHF subjects without leucopenia. ( 95% CI: 1.2-6.6). Increasing hematocrite was found as a confounding variable with (ORa: 4.0 ; 95% CI: 1.7-9.5). As conclusion, leucopenia could be a predictor of progression DHF to DSS