Background: The Indonesian Ministry of Health developed adistrict essential health package (EHP) costing software in2009. However, this has not yet been utilized due to poordissemination. It is necessary to conduct a study evaluatingthe opinion of health professionals towards intention to usethis software and ensure its usefulnessAim: This paper aims to assess user acceptance of districtEHP costing software by integrating Technology AcceptanceModel (TAM) and End User Computing (EUC) satisfaction.Method: A descriptive study was used. A total of 139respondents were involved in this study. They were policymakers and budget analysts of EHP in district health offices,and also primary health care workers and district hospitalworkers in all districts of Yogyakarta. Data were collected toassess the perceived usefulness, ease of use, content, format,accuracy, timeliness, attitude toward use and behavioralintention to use. Path diagram analysis was conducted.Result: The study showed that the respondents have theintention to use the EHP software. Usefulness and satisfactionhad the greatest positive influence on higher intention to useEHP costing software and were found to be statisticallysignificant, (0.29 and 0.22 respectively). Both the usefulnessand ease of use had positive influence on attitudes, (0.45 and0.23 respectively). Ease of use, content, accuracy andtimeliness gave a positive effect to satisfaction.Conclusion: Intention to use the EHP costing software wasmostly driven by perceived usefulness and satisfaction.Adequate human resources and hardware need to be in placefor its implementation