Uji Efek Ekstrak Biji Alpukat (Persea Americana Mill.) Terhadap Kadar Kolesterol Total Pada Tikus Wistar (Rattus Norvegicus)

Abstract

: Indonesia is a tropical country that has more than 1,000 kinds of medicinal plants. Medicinal plant is the use of part(s) of plants as ingredients in traditional medicine or synthetic drugs. One of the traditional medicine is avocado. Several studies have concluded that the avocado fruit and leaves can reduce total blood cholesterol levels while the seed is used in Nigeria for treating hypertension. This was an experimental study. Samples consisted of 12 male Wistar rats, divided into 4 groups (3 rats in each group). The treated groups were given propylthiouracil (PTU) for 14 days then the rats were given 125 mg/kg or 250 mg/kg of avocado seed extract for 14 days. The positive control group was given PTU 8 mg/rat for 14 days, followed by simvastatin 0.2 mg for 14 days. The negative control group was only given food and water. The results showed that the average level of total blood cholesterol in Wistar rats after treated with 125 mg/kg and 250 mg/kg avocado seed extract decreased by 18.1% and 31.2%, respectively. Conclusion: Avocado seed extract had an effect in reducing total blood cholesterol of Wistar rats