Background: Post anesthesia shivering is common complication after get anesthesia.It can causes discomfort situation and so many risk.Post shivering anesthesia must be prevented.Ketamin is derivate of phencyclidine which is has analgesic effect as same as meperidine as commonly drug to prevent shivering post anesthesia.Objective: the aim of this study is to prove that giving intra venous ketamine 0,25 mg kg-1 as soon before the end of surgery is effective to prevent shivering after general anesthesia.Methods: this is an observational study with cross sectional design.Using second data which consists of 48 patient with range of age is 16-60 years old underwent elective surgery with general anesthesia.At the end of surgery,they divided into two groups which one receive intravenous ketamine 0,25 mg kg-1 and the other receive NaCl 0,9%.After that the data were processed using computer program.Data analyses were done by using Chi square,Mann whitney test,and independent sample T-test.Results: Characteristic data show there were not significantly different(p>0,05).There are 4(16.6%) people shivering after receive ketamine which 3 people are suffer 1st degree and 1 person suffer 2nd degree.In Salin group there are 13(54.16%) people shivering,3 people are suffer 1st degree,6 people suffer 2nd degree,2 people are suffer 3rd and also 2 people suffer 4th degree which both oh ketamine and salin groups were not significantly different (p>0,05).Conclusions: Ketamine 0,25 mg kg-1 is effective for prevention of shivering after general anesthesia