. The aim of this study was to evaluate the effectiveness of vaccination program analysis method using the 2 x 2 contingency table to provide better assessment to the vaccination program management and implementation. This study used survey methods. A total of 230 serum samples from vaccinated chickens and 20 serum samples from unvaccinated chickens were used. The blood serum samples were then examined with the Hemagglutination Inhibition Test/HI to measure antibody levels. The data were analyzed using a 2 x 2 contingency table. Results showed that the level of vaccine protection was 68.92% with 31.31% vaccines failure rate, the level of natural protective immunity in samples was 0%, 100% vaccines specificity and the effectiveness of the vaccine was 71.20%