Uji Efek Analgesik Ekstrak Daun Mahkota Dewa (Phaleria Macrocarpa) Pada Mencit (Mus Musculus)

Abstract

The plant of Mahkota Dewa is a traditional plant which is used as a medicinal plant whose benefits are located in almost parts where it contains flavonoid and saponin compounds that have a variety of effects and one of them is analgesic effect. This research aims to determine the analgesic effect of the extract of Mahkota Dewa leaf (Phaleria macrocarpa) in mices (Mus musculus). This research uses an experimental method using nine male and female mices which are divided into three groups: the positive control group that was given aspirin and the negative control that was given aquades and the treatment group that was given the extract of the Mahkota Dewa leaf. The research is done by giving the stimulus of pain in the form of heat 55o.C and then observes the response of the tested animal such as jumping or licking its legs and at the minute of 0 before treatment, and at the minutes of 30, 60, 90, 120 after the treatment. The average value of the number of respons of mices which were given the extract of the Mahkota Dewa leaf decreases from the 30th minute until the 90th minute. Conclusion. The extract of Mahkota Dewa leaf has an analgesic effect in Mouse