A.L. Hazel

C.A. Cobbold

C.A. Converse

C.J. Packard

C.K. Glass

D.K. Spady

E. August

F. Pont

G.M. Cooper

H.H. Hobbs

J. Eisenfled

J.A. Jacquez

J.L. Goldstein

J.M. Dietschy

K. H. Parker

K.G. Parhofer

L. Dugard

M. Barahona

M. Chopra

R.P. Bywater

S.G. Young

T.E. Willnow

Y. Stein

Bulletin of Mathematical Biology

27/11/12/ mebDear Professor Barahona, 

Re: 
Stability of graph communities across time scales
Flow graphs: Interweaving dynamics and structure
A dynamical model of lipoprotein metabolism

Thank you for your submissions  to Spiral .Could you please advice on the version of the paper you uploaded using the arXiv source. I have not been able to assess if this is an author version peer-reviewed or is it an author  version non peer reviewed.  Spiral digital repository only accept peer-reviewed papers. 
27/11/12 meb Auhtor confirmed version is peer reviewed, OK to pub.We present a dynamical model of lipoprotein metabolism derived by combining a cascading process in the blood stream and cellular level regulatory dynamics. We analyse the existence and stability of equilibria and show that this low-dimensional, nonlinear model exhibits bistability between a low and a high cholesterol state. A sensitivity analysis indicates that the intracellular concentration of cholesterol is robust to parametric variations while the plasma cholesterol can vary widely. We show how the dynamical response to time-dependent inputs can be used to diagnose the state of the system. We also establish the connection between parameters in the system and medical and genetic conditions

A dynamical model of lipoprotein metabolism

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